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A regiospecific total synthesis of ellipticine via nitrene insertion

✍ Scribed by R.Bryan Miller; Sundeep Dugar

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 183 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)95184-0

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✦ Synopsis

Ellipticine, a 6H-pyrido[4,3_b]carbazole alkaloid, has been regiospecifically synthesized by a general route which should allow for the preparation of a number of derivatives. The approach employs a versatile coupling reaction between phenylboronic acid and a substituted bromoisoquinoline followed by carbazole ring formation via a nitrene insertion reaction to give ellipticine.

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