A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells

Induction of cytotoxicity in human lung

Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-α-tocotrienol, a redox-silent derivative of α-tocotrienol

✍ Yoshihisa Yano; Haruna Satoh; Keiko Fukumoto; Itsumaro Kumadaki; Tomio Ichikawa; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 509 KB

## Abstract Tocotrienols are one of the most potent anticancer agents of all natural compounds and the anticancer property may be related to the inactivation of Ras family molecules. The anticancer potential of tocotrienols, however, is weakened due to its short elimination half life __in vivo__. T