A redefinition of the Asp-Asp domain of reverse transcriptases
✍ Scribed by A. M. Velasco; L. Medrano; A. Lazcano; J. Oró
- Book ID
- 104649010
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 610 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-2844
No coin nor oath required. For personal study only.
✦ Synopsis
The rules defining the Asp-Asp domain of RNA-dependent polymerases deduced by Argos (1988) were tested in a set of 53 putative reverse transcriptases (RTs) sequences. Since it was found that some of these rules are not followed by RTs coded by bacteria, group II introns, and non-LTR retrotransposons, we present here a more strict definition of the Asp-Asp domain.
📜 SIMILAR VOLUMES
## Abstract The observation of the Asp–His–Ser triad (Asp: aspartate, His: histidine, Ser: serine) triad both in mammalian and bacterial proteases suggests a special efficiency. A series of B3LYP/D95\*(d,p) calculations on various [X–H^β^Y]^−^ dyads (as part of the [X–H^β^Y–H^α^Ac]^−^ model triad,