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A recombinant anti-erbB2, scFv-Fc-IL-2 fusion protein retains antigen specificity and cytokine function

✍ Scribed by Ming Shi; Zhigang Xie; Jiannan Feng; Yingxun Sun; Ming Yu; Beifen Shen; Ning Guo


Book ID
110437986
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
103 KB
Volume
25
Category
Article
ISSN
0141-5492

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✍ Claudia Heuser; Stefan Guhlke; Alexander Matthies; Hans Bender; Stefan Barth; Vo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 235 KB

## Abstract The pathogenesis of Hodgkin's disease (HD) is associated with the accumulation of functionally anergic T cells in the near vicinity of the malignant Hodgkin/Reed‐Sternberg (H/RS) cell. To stimulate locally the anti‐tumour immunity in Hodgkin's disease, we generated an anti‐CD30‐antibody