A reassessment of biochemical marker distributions in trisomy 21-affected and unaffected twin pregnancies in the first trimester
✍ Scribed by H. N. Madsen; S. Ball; D. Wright; N. Tørring; O. B. Petersen; K. H. Nicolaides; K. Spencer
- Book ID
- 112230950
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 120 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0960-7692
- DOI
- 10.1002/uog.8845
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In a study of 130 ®rst trimester cases of trisomy 21 and 959 controls we have shown that the median MoM for alpha-fetoprotein (AFP) is lower (0.82) and that for total human chorionic gonadotrophin (hCG) is higher (1.31) than in the control group. For AFP 15.3% of cases were below the 5th centile and
In the ®rst trimester of pregnancy the biochemical markers free b-hCG and pregnancy associated plasma protein-A (PAPP-A) are used for the prenatal screening of trisomy 21, either alone or in combination with nuchal translucency (NT) thickness. In this study, I have analysed the distribution of these