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A real time reaction monitoring using fluorescent dansyl group as a solid-phase leaving group

✍ Scribed by Toshiro Suenaga; Caroline Schutz; Tadashi Nakata

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 154 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01406-0

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✦ Synopsis

A real time monitoring method to monitor the progress of the solid-phase reaction has been developed. The substitution reaction on the solid-phase was clearly monitored as a change in the color depth using the fluorescent dansyl group as the leaving group. This methodology is applicable to both parallel and split combinatorial synthesis.

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