A re-examination of the gas chromatographic determination of α-d-propoxyphene

✍ Scribed by C.M. Sparacino; E.D. Pellizzari; C.E. Cook; M.W. Wall

• Book ID: 104143955
• Publisher: Elsevier Science
• Year: 1973
• Tongue: English
• Weight: 348 KB
• Volume: 77
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)92210-6

✦ Synopsis

Note

A re-examination of the gas chromatographic determination of a-d-propoxyphene A nutnbcr of reports hnvc been published

on the gas chromatograpllic cletcrmination of a-tl-l)rol~osyl~llcl~c (Darvon) in blood1 and plasmas-4 samples, TIE need for a quantitation proccdurc in our laboratories led to an esamination of these mctliocls, which were found to IJC gcncrally inaclcquatc.

Sigriificnnt amounts of clccomposition at low masses of n-rl-propoxypllcne were reported on cliffcrcnt column paclcin@~~. However, WolxN hNr> Gnunrsl@ clescrihd the successful detcrniination of plasma lcvcls of a-&proposyplicnc usinfi a rather short (30 cm) column of UC-WgS on Diatoport S. Decomposition was not ohservecl J, but low column efficiencies were obtained (cn, 375 theoretical plates), which limits separation of complex mixtures such as nii@it be cncountcrccl with 11100c1 or plasma cstracts.

More importantly the column packing usecl in this proceclure (Diatoport S, I-Iewlctt-Pa&arc1

Co., Avondale,