A re-analysis of the association between rheumatoid arthritis with and without extra-articular features, HLA-DR4, and DR4 subtypes
✍ Scribed by M. C. Hillarby; J. Hopkins; D. M. Grennan
- Book ID
- 115094185
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 278 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0001-2815
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Objective. To analyze HLA-DR4 alleles in New Zealand Polynesians with rheumatoid arthritis (RA). Methods. Thirty Polynesians and 30 Caucasians with RA, as well as 65 Polynesian and 60 Caucasian healthy blood donors, were DR4 subtyped using the polymerase chain reaction and sequence-specific oligonu
Susceptibility to rheumatoid arthritis (RA) maps to residues QKRAA/QRRAA in the third hypervariable region of the HLA DRI31 chain. Peptides from the same area of MHC class II molecules are able to modulate the T-cell repertoire by deleting self-reactive T-cells. The Epstein Barr virus glycoprotein g