The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ¼ 21 nM, 5-HT 7 ¼ 234 nM) are reported. To affect the affinity for 5-
A rationale for the activity profile of arylpiperazinylthioalkyls as 5-HT1A-serotonin and α1-adrenergic receptor ligands
✍ Scribed by Brij Kishore Sharma; Kirti Sarbhai; Prithvi Singh
- Book ID
- 108116391
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 306 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0223-5234
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