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A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

✍ Scribed by J. C. A. Broen; L. Bossini-Castillo; L. van Bon; M. C. Vonk; H. Knaapen; L. Beretta; B. Rueda; R. Hesselstrand; A. Herrick; J. Worthington; N. Hunzelman; C. P. Denton; C. Fonseca; G. Riemekasten; H. P. Kiener; R. Scorza; C. P. Simeón; N. Ortego-Centeno; Spanish Systemic Sclerosis Group; M. A. Gonzalez-Gay; P. Airò; M. J. H. Coenen; J. Martín; T. R. D. J. Radstake

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 181 KB
Volume: 64
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.33325

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Local expression of the serum amyloid A and formyl peptide receptor–like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis

✍ Rosemary O'Hara; Evelyn P. Murphy; Alexander S. Whitehead; Oliver FitzGerald; Ba 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 336 KB 👁 2 views

## Abstract ## Objective To evaluate the regulation of acute‐phase serum amyloid A (A‐SAA) production in inflamed synovial tissue, and to elucidate a possible pathophysiologic role in the induction of matrix metalloproteinase (MMP) release by fibroblast‐like synoviocytes (FLS). ## Methods Synovi