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A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases

✍ Scribed by Robert A. Furlong; Luk W. Ho; Judy S. Rubinsztein; Albert Michael; Cathy Walsh; Eugene S. Paykel; David C. Rubinsztein


Book ID
117478233
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
230 KB
Volume
277
Category
Article
ISSN
0304-3940

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No association of the tryptophan hydroxy
✍ Furlong, Robert A.; Ho, Luk; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Eugene πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 10 KB πŸ‘ 2 views

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylas

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Tyrosine hydroxylase (TH) is the ratelimiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, asso

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It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)