A Rapid Screening Procedure for Quaternary Ammonium Compounds in Fluids and Tissues with Special Reference to Suxamethonium (Succinylcholine)
✍ Scribed by H.M. Stevens; A.C. Moffat
- Publisher
- Elsevier
- Year
- 1974
- Tongue
- English
- Weight
- 669 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0015-7368
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✦ Synopsis
The extraction ofsuxamethonium jrom urine samples in the form of its ion-pair complex with bromothymol blue is described. Detection of the drug was accomplished calorimetrically and enzymically using two thin-layer chromatography systems, and one gas chromatographic method.
A brief study was made of the stability of suxamethonium at various p H values which affect its storage in urine for different periods of time.
The extraction technique and colorimetric method of detection were applied to other quaternary ammonium compounds, some of which had been recovered from blood and urine after addition to thesejuids. This work also included a short study of the efect of certain tertiary amine drugs ifpresent in the urine with the quaternary compounds.