Discovery of a novel hybrid from finaste
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Zhiyi Yao; Yingjun Xu; Minmin Zhang; Sheng Jiang; Marc C. Nicklaus; Chenzhong Li
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Article
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2011
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Elsevier Science
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English
⚖ 617 KB
a b s t r a c t Finasteride and epristeride both inhibit 5a-reductase with high potency via competitive and non-competitive mechanism, respectively. A new hybrid of finasteride and epristeride was designed as a new 5a-reductase inhibitor based on combination principles in medicinal chemistry. Human