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A rapid assay for measuring the metabolism of [3H]-retinoic acid in cell cultures

✍ Scribed by Thomas A. Garrabrant; David W. End


Book ID
113409949
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
494 KB
Volume
34
Category
Article
ISSN
1056-8719

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## Abstract A ^3^H^+^‐release method has been developed for the assay of β‐hydroxylation of the adrenolytic drug mitotane. β‐^3^H‐mitotane was synthesized by the reduction of 1‐(2‐chlorophenyl)‐1‐(4‐chlorophenyl)‐2,2,2‐trichloroethane by an aluminium‐Hg~2~Cl~2~ couple in the presence of ^3^H~2~O. F