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A rapid and sensitive LC/ESI–MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study

✍ Scribed by Hiroaki Yamaguchi; Asuka Fujikawa; Hajime Ito; Nobuaki Tanaka; Ayako Furugen; Kazuaki Miyamori; Natsuko Takahashi; Jiro Ogura; Masaki Kobayashi; Takehiro Yamada; Nariyasu Mano; Ken Iseki

Book ID: 113687682
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 420 KB
Volume: 893-894
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2012.02.003

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## ABSTRACT A highly sensitive and specific LC‐MS/MS‐ESI method was developed for simultaneous quantification of albenadazole (ABZ) and ricobendazole (RBZ) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract ABZ and RBZ from rat plas