✦ LIBER ✦

A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma

✍ Scribed by James N. Ingle; Vera J. Suman; Carl G. Kardinal; James E. Krook; James A. Mailliard; Michael H. Veeder; Charles L. Loprinzi; Robert J. Dalton; Lynn C. Hartmann; Cheryl A. Conover; Michael N. Pollak

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 110 KB
Volume: 85
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990315)85:6<1284::aid-cncr10>3.0.co;2-p

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✦ Synopsis

BACKGROUND.

Tamoxifen (TAM) is generally considered the hormonal agent of choice for postmenopausal women with hormone receptor positive breast carcinoma. The somatostatin analogues, including octreotide, have demonstrated inhibition of breast carcinoma cell lines and multiple endocrinologic actions, including reduction of insulin-like growth factor I (IGF-I), a potent mitogen for breast carcinoma cells. In an attempt to improve the efficacy of TAM, this randomized trial was performed.

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