A randomized multicenter trial of thymosin-α1 vs IFN-α treatment in patients with HbeAb and HBV-DNA positive chronic active hepatitis
- Book ID
- 118566605
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 142 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0168-8278
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Thymosin ␣ 1 (T␣) is an immune modifier that has been shown in a pilot study to be effective for chronic hepatitis B; this requires confirmation. Ninety-eight patients with clinicopathologically proven chronic hepatitis B were randomly allocated to 3 groups: 1) group A received a 26-week course of T
ment for anti-HBe-positive chronic hepatitis. The benefit It has recently been shown that thymosin-a 1 (T-a 1 ), a of this agent in producing long-term inhibition of HBV synthetic polypeptide of thymic origin, is able to proreplication must be confirmed by future trials. (HEPAmote disease remission
Hepatitis C is a major cause of liver disease leading to cirrhosis. Although interferon (IFN) is the only approved therapy, treatment is characterized by low response rates and dose-limiting side effects. We evaluated the addition of thymosin ␣1 (TA1), an immunomodulatory peptide, to the standard tr