✦ LIBER ✦
A randomized comparison of metoclopramide and domperidone on plasma aldosterone concentration and on spironolactone-induced diuresis in ascitic cirrhotic patients
✍ Scribed by Agesilao D-Arienzo; Gabriella Ambrogio; Pasqualina Di Siervi; Enzo Perna; Giovanni Squame; Gabriele Mazzacca
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 338 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of metoclopramide and domperidone, two dopamine antagonists, administered to cirrhotic patients with ascites and secondary hyperaldosteronism, was examined to evaluate the changes in plasma aldosterone levels and in spironolactone-induced diuresis.
In 15 patients with ascites and secondry hyperaldosteronism, the intravenous administration of 10 mg metoclopramide significantly increased plasma aldosterone levels (23%, p < 0.01). This