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A randomised phase II trial of weekly high-dose 5-fluorouracil with and without folinic acid and cisplatin in patients with advanced biliary tract carcinoma: results of the 40955 EORTC trial

✍ Scribed by M. Ducreux; E. Van Cutsem; J.L. Van Laethem; T.M. Gress; K. Jeziorski; P Rougier; T. Wagener; O. Anak; B. Baron; B. Nordlinger


Book ID
116428407
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
128 KB
Volume
41
Category
Article
ISSN
0959-8049

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A phase II trial of weekly high dose con
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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer