A Radioactive Binding Assay for Inhibitors of trkA Kinase
โ Scribed by Ernest Knight Jr.; Thomas J. Connors; Anna C. Maroney; Thelma S. Angeles; Robert L. Hudkins; Craig A. Dionne
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 122 KB
- Volume
- 247
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Two quantitative, high-throughput cell-based assays for evaluating inhibitors of NGF-stimulated trkA phosphorylation in trkA-transfected NIH3T3 cells have been established. Both assays involve capture of the trkA receptor from cell lysates in microtiter plates coated with an anti-trk antibody. The a
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ribonuclease A (RNase A) and the ribonuclease inhibitor protein (RI) form one of the tightest known protein-protein complexes. RNase A variants and homologues, such as G88R RNase A, that retain ribonucleolytic activity in the presence of RI are toxic to cancer cells. Herein, a new and facile assay i