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A radiation-controlled molecular switch for use in gene therapy of cancer

✍ Scribed by Scott, S D; Marples, B; Hendry, J H; Lashford, L S; Embleton, M J; Hunter, R D; Howell, A; Margison, G P

Book ID
110038716
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
145 KB
Volume
7
Category
Article
ISSN
0969-7128

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## Abstract We present a tumor gene therapy approach based on the use of regulatory sequences of the H19 gene that are differentially expressed between normal and cancer cells. We constructed expression vectors carrying the gene for the A fragment of diphtheria toxin (DT‐A) or herpes simplex virus