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A Quantum Chemical Study of the Reaction Mechanism of Acetyl-Coenzyme A Synthase

โœ Scribed by Amara, Patricia; Volbeda, Anne; Fontecilla-Camps, Juan Carlos; Field, Martin J.


Book ID
120530048
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
194 KB
Volume
127
Category
Article
ISSN
0002-7863

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Acetyl-CoA enolization in citrate syntha
โœ Adrian J. Mulholland; W. Graham Richards ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 202 KB ๐Ÿ‘ 1 views

Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis. The rapid reaction rate is puzzling because of the instability of the postulated nucleophilic intermediate, the enolate of acetyl-CoA. As altern