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A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain

✍ Scribed by R. Mark Henkelman; Jeffrey J. Neil; Qing-San Xiang

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
526 KB
Volume
32
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Pulsed gradient spin echo (PGSE) sequences have been used to measure the signal loss of ^19^F in perfluorinated hydrocarbon blood substitutes moving within the vasculature of the rat brain in the experimental conditions of the study. The signal loss is not characterized by a single apparent pseudodiffusion coefficient. A simple vascular network model based on self‐similarity hss been used to calculate the shape of the signal loss. Excellent agreement with the experiment has been obtained showing that the IVlM measurements are sensitive to flow over a wide range of vessel diameters and flow rates. This model of vascular structure may serve well for other MR measurements that are sensitive to perfusion.

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