A QSAR Study of the Antimalarial Activity of Some Synthetic 1,2,4-Trioxanes
β Scribed by Grigorov, M.; Weber, J.; Tronchet, J.M.J.; Jefford, C.W.; Milhous, W.K.; Maric, D.
- Book ID
- 126068164
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 502 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0095-2338
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π SIMILAR VOLUMES
The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti
The vibrational spectra of some 1,2,4-trioxanes present two characteristic bands at 790 and 880 cm-'. On the basis of "0-isotopic substitution and comparison with analogous compounds, these bands have been assigned to coupled C-0 and 0-0 stretching modes of the C-0-0 element. ## Introduction. -Ev
Two pairs of enantiomerically pure cis-fused cyclopenteno-l,2,4-trioxanes (7, en!-7 and 8, ent-8) are prepared (Schemes 1-3). Their identities are established by dye-sensitized photo-oxygenation of ent-7 and 8 to the allylic hydroperoxides, reduction to the corresponding alcohols, and conversion to
Two sets of tricyclic 1,2,4-trioxanes containing the ABC (10, 11) and ACD ring portions (21, 22, 32, 33, 37, and 38) of artemisinin (1) were synthesized by successive photo-oxygenation of appropriate enol-ether precursors to 1,2-dioxanes and inter-and intramolecular reaction with a carbonyl compound