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A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)

✍ Scribed by Brian B. Hasinoff; Theodore I. Kuschak; Jack C. Yalowich; Andrew M. Creighton


Book ID
115784345
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
642 KB
Volume
50
Category
Article
ISSN
0006-2952

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## Background Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise t