Characterisation of cytotoxicity and DNA
β
Lars H Jensen; Marielle Dejligbjerg; Lasse T Hansen; Morten Grauslund; Peter B J
π
Article
π
2004
π
BioMed Central
π
English
β 748 KB
## Background Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise t