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A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2

✍ Scribed by Kuokkanen, Satu; Sundvall, Mats; Terwilliger, Joseph D.; Tienari, Pentti J.; Wikström, Juhani; Holmdahl, Rikard; Pettersson, Ulf; Peltonen, Leena


Book ID
109916730
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
450 KB
Volume
13
Category
Article
ISSN
1061-4036

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Radiation-induced acute myeloid leukemias (AMLs) in the mouse are characterized by chromosome 2 deletions. Previous studies showed that a minimal deleted region (mdr) of ϳ6.5 cM is lost from one homologue in chromosome 2-deleted AMLs. An AML tumor suppressor gene is proposed to map within this mdr.