A psychopharmacological study to assess anti-muscarinic and central nervous effects of medifoxamine in normal volunteers
✍ Scribed by M. A. Randhawa; A. Hedges; A. Johnston; P. Turner
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 315 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
Ten volunteers received single oral doses of medifoxamine 50 and IOOmg, atropine 1 mg, amitriptyline 50mg or placebo in random order based on a Latin square design under double-blind conditions. Tests of anti-rnuscarinic and central nervous activity were carried out at hourly intervals for 6 hours. The tests were measurements of salivary volume, heart rate, pupil diameter, manual dexterity, choice reaction time, critical flicker frequency, and visual analogue rating scales for sedation, dryness of mouth, appetite, nausea and quality of sleep. The positive controls atropine and amitriptyline produced effects which were significantly different from placebo, but neither dose of medifoxamine produced any anti-muscarinic activity nor influenced alertness. KEY worn-Medifoxamine, antidepressant, anti-muscarinic activity, CNS activity.