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A protocol and guide for the in vitro rat hepatocyte DNA-repair assay

โœ Scribed by Byron E. Butterworth; John Ashby; Edilberto Bermudez; Daniel Casciano; Jon Mirsalis; Gregory Probst; Gary Williams


Book ID
119092980
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
763 KB
Volume
189
Category
Article
ISSN
0165-1218

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The induction of unscheduled DNA synthesis (UDS) in rat primary hepatocytes is used as an in vitro screen for genotoxicity. The purpose of this study was to develop criteria for statistical evaluation of autoradiographic grain counts from the UDS assay. Based on our historical solvent control popula