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A Protective Role for Cyclooxygenase-2 in Drug-Induced Liver Injury in Mice †

✍ Scribed by Reilly, Timothy P.; Brady, John N.; Marchick, Michael R.; Bourdi, Mohammed; George, John W.; Radonovich, Michael F.; Pise-Masison, Cynthia A.; Pohl, Lance R.

Book ID
125953199
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
998 KB
Volume
14
Category
Article
ISSN
0893-228X

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## Cyclooxygenase -2 (COX-2) is upregulated in many cancers, and the prostanoids synthesized increase proliferation, improve angiogenesis, and inhibit apoptosis in several tissues. To explore the function of COX-2 in liver, transgenic (Tg) mice were generated containing a fusion gene (LIVhCOX-2) c