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A Protecting-Group-Free Route to Chiral BINOL–Phosphoric Acids

✍ Scribed by Baojian Li; Pauline Chiu

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 429 KB
Volume: 2011
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201100328

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✦ Synopsis

Abstract

A two‐step, protecting group‐free route for the synthesis of 3,3′‐disubstituted and 6,6′‐disubstituted chiral BINOL–phosphoric acids has been realized starting from commercially available brominated BINOLs. This synthesis relies on the direct Suzuki coupling of brominated BINOL phosphoric acids. This synthetic strategy is more efficient compared to previous circuitous strategies involving protections and deprotections, and the process is higher yielding relative to the alternative two‐step synthesis involving Suzuki coupling of the BINOL.

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