𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A prospective investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers

✍ Scribed by Unhee Lim; D. Michal Freedman; Bruce W. Hollis; Ronald L. Horst; Mark P. Purdue; Nilanjan Chatterjee; Stephanie J. Weinstein; Lindsay M. Morton; Arthur Schatzkin; Jarmo Virtamo; Martha S. Linet; Patricia Hartge; Demetrius Albanes

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
218 KB
Volume
124
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non‐Hodgkin lymphoma (NHL). Ultraviolet radiation‐derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25‐hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case–control study nested within the Alpha‐Tocopherol Beta‐Carotene Cancer Prevention Study cohort (1985–2002) of 29,133 Finnish male smokers (ages 50–69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth‐year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% confidence interval (CI), 0.50, 1.14) and 0.82 (95% CI, 0.53, 1.26). The 25(OH)D‐NHL association, however, differed by follow‐up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.83; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short‐term risk of NHL. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Plasma 25-hydroxyvitamin D and premenopa
Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study
✍ Sascha Abbas; Jenny Chang-Claude; Jakob Linseisen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 112 KB 👁 2 views

## Abstract Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential eff

Obesity and increased risk of cancer: Do
Obesity and increased risk of cancer: Does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association?
✍ Zoya Lagunova; Alina C. Porojnicu; William B. Grant; Øyvind Bruland; Johan E. Mo 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

## Abstract Low levels of vitamin D and excess body weight are both factors associated with increased risk of cancer. The increased risk seems to be proportional to the increase in BMI, and to decrease in serum 25‐hydroxyvitamin D (25(OH)D) level. Our earlier investigations suggest that serum 25(OH

Serum 25-hydroxyvitamin D and clinical f
Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: The women's health initiative (WHI)
✍ Jane A Cauley; Michelle E Danielson; Robert Boudreau; Kamil E Barbour; Mara J Ho 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 147 KB 👁 2 views

## Abstract Low 25‐hydroxyvitamin D [25(OH)D] levels have been linked to hip fracture in white women. To study the association of 25(OH)D with risk of fracture in multiethnic women, we performed a nested case‐control study within the prospective Women's Health Initiative (WHI) Observational Study.

Meta-analysis of observational studies o
Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma
✍ Sara Gandini; Mathieu Boniol; Jari Haukka; Graham Byrnes; Brian Cox; Mary Jane S 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 331 KB 👁 1 views

## Abstract Epidemiological studies have suggested a reduced risk of several cancers associated with high vitamin D status. We performed a systematic review with meta‐analyses of observational studies of serum 25‐hydroxyvitamin D level and colorectal, breast and prostate cancer and colonic adenoma.

High serum 25-hydroxyvitamin D is associ
High serum 25-hydroxyvitamin D is associated with a low incidence of stress fractures
✍ Alina A Burgi; Edward D Gorham; Cedric F Garland; Sharif B Mohr; Frank C Garland 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 165 KB

## Abstract Low serum 25‐hydroxyvitamin D [25(OH)D] concentrations are associated with hip fractures, but the dose‐response relationship of serum 25(OH)D with risk of stress fractures in young women is unknown. This nested case‐control study in a cohort of female Navy recruits was designed to deter