A prospective evaluation of the leukocyte adherence inhibition test in colorectal cancer and its correlation with carcinoembryonic antigen levels

✍ Scribed by Adi Shani; Dr. R. E. Ritts Jr.; G. S. Thynne; Louis H. Weiland; Abraham Silvers; Charles G. Moertel; V. L. W. Go

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 615 KB
• Volume: 22
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910220202

✦ Synopsis

Abstract

Fifty‐four patients from the surgical gastroenterology service and 22 healthy controls have been prospectively evaluated in a single‐blind protocol by the LAI tube method. The LAI correctly identified 25 of 33 early colorectal patients staged as Dukes' B and C at surgery but none of the Dukes' D patients. An inverse relationship was seen between the results of the non‐adherence index (NAI) and CEA levels which was most pronounced in those with advanced colorectal cancer. The majority of Dukes' B and C patients having a “false negative” LAI had a CEA level greater than 2.5 ng/ml, suggesting that more advanced disease than that seen at surgery may be present. Two of 22 normal controls gave a borderline positive NAI. Some technical problems, including the relatively short life of the tumor extracts, are discussed.