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A proposed mechanism of action of 1-β-d-arabinofuranosyl-cytosine as an inhibitor of the growth of leukemic cells

✍ Scribed by M.Y. Chu; G.A. Fischer


Book ID
115768393
Publisher
Elsevier Science
Year
1962
Tongue
English
Weight
402 KB
Volume
11
Category
Article
ISSN
0006-2952

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## Abstract The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation