✦ LIBER ✦

A program to simulate drug elimination interactions: Warfarin and BSP — An illustrative example

✍ Scribed by Richard H. Luecke; Walter D. Wosilait

Book ID: 103052153
Publisher: Elsevier Science
Year: 1978
Weight: 526 KB
Volume: 8
Category: Article
ISSN: 0010-468X
DOI: 10.1016/0010-468x(78)90057-0

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✦ Synopsis

The kinetics of drug elimination in interactive drug systems is simulated by a set of differential equations based on mass balances, the mass of organs and blood flow rates. Experimentally determined concentration profiles of the drugs in the plasma and bile are used to evaluate clearance rate parameters. An example is shown in which the clearance of the anticoagulant warfarin is reduced to less than 50% of its normal rate due to the interference by BSP.

Drug interactions

Warfarin tolbutamide Bromosulfophthalein Bile

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