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A process of stereoselective preparation of 2-substituted succinic derivatives


Book ID
114080830
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
304 KB
Volume
33
Category
Article
ISSN
1873-3298

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Enzymatic preparation of homochiral 2-is
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An efficient enzymatic procedure for the enantio-and regioselective monohydrolysis of diethyl 2-isobutyl succinate 3 using subtilisin Carlsberg has been developed. The product (R)-2-isobutyl succinic acid 4-ethyl ester 4, a collagenase inhibitor building block, was obtained in high enantiomeric exce