A Procedure for the Conversion of Cannabidiol into 12β-Substituted Tetrahydrocannabinols (THC's): Synthesis of 12β-Hydroxy-Δ β THC 1

Alternative procedure for the synthesis

Alternative procedure for the synthesis of enantiopure 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one, a useful starting material for the enantioselective synthesis of α-substituted β-amino acids

✍ Martı́n A. Iglesias-Arteaga; Elena Castellanos; Eusebio Juaristi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 177 KB

The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that