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A procedure for the assessment of the toxicity of intermediates and products formed during the accidental thermal decomposition of a chemical species

✍ Scribed by Ilaria Di Somma; Antonino Pollio; Gabriele Pinto; Maria De Falco; Elio Pizzo; Roberto Andreozzi


Book ID
108172414
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
384 KB
Volume
176
Category
Article
ISSN
0304-3894

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✍ Saranjit Singh; Sanjeev Kumar; Nishi Sharda; Asit K. Chakraborti πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 104 KB

The degradation behavior of famotidine (1) was investigated in 25% ammonia solution and in 2 M NaOH. The hydrolysis of the drug in ammonia resulted in separation of [3-[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propionamide (3), an impurity listed in British Pharmacopoeia. The treatment w