A probabilistic view on steady-state enzyme reactions

✍ Scribed by Alexey K. Mazur

• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 637 KB
• Volume: 148
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1016/s0022-5193(05)80342-x

✦ Synopsis

A new theoretical description of steady-state enzyme reactions is proposed. The description is based on the concepts of the probability theory instead of the conventional formalism of chemical kinetics. A general steady-state rate equation is obtained using a probabilistic model of the catalytic act. As a result, the classical problems of enzyme kinetics can be formulated and considered in a different aspect. It is shown that the new theory presents a clearer treatment of some commonly obscure questions, such as the steady-state establishment. The theory also gives additional possibilities in the interpretation of the experimental results of traditional methods and proposes certain new ways in experimental investigations of enzymes.