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A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe(4NO2)·Pro·NH2(BW443C)] in healthy volunteers

✍ Scribed by J. Posner; K. Dean; S. Jeal; S. G. Moody; A. W. Peck; G. Rutter; A. Telekes

Publisher
Springer
Year
1988
Tongue
English
Weight
534 KB
Volume
34
Category
Article
ISSN
0031-6970

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Analgesic, central, cardiovascular and e
Analgesic, central, cardiovascular and endocrine effects of the enkephalin analogue Tyr-D.Arg-Gly-Phe(4NO2)-Pro-NH2(443C81) in healthy volunteers
✍ J. Posner; S. G. Moody; A. W. Peck; D. Rutter; A. Telekes 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 680 KB

443C81 is a synthetic enkephalin thought to act on peripheral opiate receptors. The analgesic, central, cardiovascular and endocrine effects of two i.v. doses of 443C81 were investigated in 12 healthy male volunteers. Its effects were compared with those of placebo and the classical opiate dipipanon