A preliminary study of laser tissue soldering as arterial wall reinforcement in an acute experimental aneurysm model
✍ Scribed by Philip Oskoui; Istvan Stadler; Raymond J. Lanzafame
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 73 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0196-8092
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background and Objectives
Aneurysm formation results from destruction of structural arterial wall connective tissue, leading to wall weakening and rupture. The purpose of this study was to demonstrate that reinforcement of the arterial wall using laser tissue soldering contributes to arterial wall stabilization and rupture prevention in an acute experimental model.
Study Design/Materials and Methods
Elastase (10 U/mg protein, Sigma‐Aldrich Co., St. Louis, MO) was applied with a fine paint brush on femoral artery segments to cause fusiform aneurysm formation. After aneurysms formed (approximately 45 minutes after treatment), elastase was rinsed out and indocyanine green (ICG) and albumin soldering mixture (2.5 mg/ml ICG in 50% albumin) was delivered to the arterial segment, followed by laser irradiation at 830 nm, (15mW output for 20 minutes). In situ pressure burst measurements were then performed.
Results
In situ burst pressures were > 503 mmHg for normal arteries and 181 ± 26.0 mmHg, for Elastase treated segments. (P < 0.0001) Treatment of experimental aneurysms laser tissue soldering returned burst strengths to > 503 mmHg.
Conclusions
These results indicate laser tissue soldering reinforcement of weak arterial walls, is possible and may reduce the likelihood of acute rupture. Further development of this technique for aneurysm management is warranted. Lasers Surg. Med. 32:346–348, 2003. © 2003 Wiley‐Liss, Inc.