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A predicted consensus structure for the N-Terminal fragment of the heat shock protein HSP90 family

✍ Scribed by Dietlind L. Gerloff; Fred E. Cohen; Chantal Korostensky; Marcel Turcotte; Gaston H. Gonnet; Steven A. Benner

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
48 KB
Volume
27
Category
Article
ISSN
0887-3585

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✦ Synopsis

A secondary structure has been predicted for the heat shock protein HSP90 family from an aligned set of homologous protein sequences by using a transparent method in both manual and automated implementation that extracts conformational information from patterns of variation and conservation within the family. No statistically significant sequence similarity relates this family to any protein with known crystal structure. However, the secondary structure prediction, together with the assignment of active site positions and possible biochemical properties, suggest that the fold is similar to that seen in N-terminal domain of DNA gyrase B (the ATPase fragment). Proteins 27:450-458, 1997.

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