Dedicated to Professor Hitosi Nozaki on the occasion of his 60th birthday. Magnesium enolates of t-butyl (or ethyl) acetate and t-butyl propionate are found to react with nitriles to give 3-amino-2-alkenoates having Z configuration. The title compounds are versatile intermediates for the synthesis
A practical synthesis of (Z)-3-alkenoates
✍ Scribed by Yoshihiko Ikeda; Hisashi Yamamoto
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 148 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Deconjugative protonation of (E)-2-alkenoate with bulky alkoxy group using potsssium disilazide as the base gives (z)-3-alkenoate selectively.
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