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A practical synthesis of essentially enantiopure syn-propionate aldols using a chiral oxazaborolidinone-promoted asymmetric aldol reaction coupled with radical reduction

✍ Scribed by Syun-ichi Kiyooka; Kazi A. Shahid; Mostofa A. Hena

Book ID: 104262061
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 171 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01278-2

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✦ Synopsis

Essentially enantiopure syn-propionate aldols (>98% ee) were prepared by a chiral oxazaborolidinone-promoted asymmetric aldol reaction, followed by a diastereoselective radical reduction with Bu3SnH and Et3B, which was carried out under chelation control.

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