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A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (α,α-difluoro-β-alanine)

✍ Scribed by Arnaud Cheguillaume; Simon Lacroix; Jacqueline Marchand-Brynaert

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
140 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected a,a-difluoro-b-alanine. Hydrogenolysis and hydrolysis furnished a,a-difluoro-b-alanine. Further transformation into N-phthalimido-a,a-difluoro-b-alanine was described.

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