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A Practical in situ Generation of the Schwartz Reagent. Reduction of Tertiary Amides to Aldehydes and Hydrozirconation

✍ Scribed by Zhao, Yigang; Snieckus, Victor


Book ID
121883797
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
656 KB
Volume
16
Category
Article
ISSN
1523-7060

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A convenient synthesis of functionalized propargylic alcohols arising from the 1,2-addition of lithium alkynyl-trimethyl borate onto aldehydes under transition metal free mild conditions is reported. The reaction tolerates a wide range of functional groups, is highly chemoselective and the propargyl