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A Practical Chemo-enzymatic Synthesis of Homochiral Bicyclo[2.2.2]octane-2,5-dione

✍ Scribed by Luo, Yunfei; Carnell, Andrew J


Book ID
127373156
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
732 KB
Volume
75
Category
Article
ISSN
0022-3263

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## Abstract The Michael addition of dimethyl malonate (12) to __tert__‐butyl acrylate (11), carried out without solvent, affords the triester 13a in 88% yield on a kg scale. Selective partial hydrolysis of 13a produces the monoacid 13b almost quantitatively. The Kolbe electrolysis of 13b furnishes