A Practical and Green Chemical Process: Fluoroalkyldistannoxane-Catalyzed Biphasic Transesterification

✍ Scribed by Jiannan Xiang; Shinji Toyoshima; Akihiro Orita; Junzo Otera

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 68 KB
• Volume: 113
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3757(20011001)113:19<3782::aid-ange3782>3.0.co;2-f

✦ Synopsis

Transesterification is one of the most important reactions in organic synthesis. [1] Besides its utility in the laboratory, this reaction is significant in various industrial processes, such as the production of fatty acids, paints, polyesters, etc. Hence it is important that the reaction be practical and green. In its long history, numerous methods have been advanced, but few are satisfactory in view of process chemistry. The difficulty stems primarily from the equilibration of the reaction. Two strategies are invoked to bias the equilibrium in favor of the product: use of one of the reactants (RCOOR' or R''OH) in excess or continuous removal of the alcohol formed (R'OH) [Eq. ( 1)]. The former treatment is not desirable in terms of ªatom economy,º [2] but the latter is also not technically easy to realize. Another problem emerges from the use of base or acid