There are numerous statistical methods for quantitative trait linkage analysis in human studies. An ideal such method would have high power to detect genetic loci contributing to the trait, would be robust to non-normality in the phenotype distribution, would be appropriate for general pedigrees, wo
โฆ LIBER โฆ
A Powerful and Robust Method for Mapping Quantitative Trait Loci in General Pedigrees
โ Scribed by G. Diao; D.Y. Lin
- Book ID
- 117854641
- Publisher
- American Society of Human Genetics
- Year
- 2005
- Tongue
- English
- Weight
- 943 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/431683
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In a segregating population a quantitative trait may be considered to follow a mixture of (normal) distributions, the mixing proportions being based on Mendelian segregation rules. A general and flexible mixture model is proposed for mapping quantitative trait loci (QTLs) by using molecular markers.