A potentially general intramolecular biaryl coupling approach to optically pure 2,2′-BINOL analogs

✍ Scribed by Bruce H. Lipshutz; Brian James; Shelly Vance; Isaac Carrico

• Book ID: 104256198
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 216 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02453-7

✦ Synopsis

Tethering of two equivalents of mono-protected 2,7-dihydroxynaphthalene gives an intermediate which allows for eventual copper-catalyzed intramolecular biaryl coupling to afford a new nonracemic BINOL documenting a new strategy to modified binaphthyl ligands.