## Abstract Sucrose polyester (a dietary fat substitute) opacifies the entire gastrointestinal tract of the rat with oral administration in magnetic resonance imaging (MRI). These results suggest the potential use of this material as an oral contrast agent for human abdominal MRI studies. Β© 1991 Ac
A potentially artifact-free oral contrast agent for gastrointestinal MRI
β Scribed by Thomas Liebig; Christophoros Stoupis; Pablo R. Ros; J. Ray Ballinger; Richard W. Briggs
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 381 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components that can potentially eliminate susceptilbllity artifacts even with gradient echo pulse sequences. The relaxation properties that make the SPIO suspension a useful negative contrast agent are retained.
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## Monoclonal antibodies (MAbs ) 19-9 and 73-3 specific for human colon adenocarcinoma were labelled with a high number of gadolinium atoms. Twenty five DTPA were chelated per MAb, with only slight loss of immunoreactivity. The NMR contrast agent Gd-25 DTPA-MAb 19-9 or 73-3 ([Gd] 17 pmole/kg, [MAb
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